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CCT128930 (hydrochloride)

CCT128930 (hydrochloride)

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Amount	10 mg
Item no.	HY-13260A-10mg
Targets	Akt; Autophagy; Apoptosis
CASRN	2453324-32-6
eClass 6.1	32169090
eClass 9.0	32169090
Available
Purity	98.32
Product Description	CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50=6 nM). CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. Antitumor activity[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	378.30
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Akt; Apoptosis; Autophagy
Isoform	Akt2
Pathway	Apoptosis; Autophagy; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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