Ned-K

Item no.	HY-131041-1ea
Manufacturer	MedChem Express
CASRN	2250019-90-8
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Formula	C31H31N5O3
Citations	[1]Sean M Davidson, et al. Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc Res. 2015 Dec 1;108(3):357-66.
Smiles	O=C([C@H]1N[C@@H](C2=C(C1)C3=C(N2)C=CC=C3)C4=CC=C(C(CN5CCN(CC5)C6=CC=CC=C6C#N)=C4)OC)O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes[1].
Shipping	Room temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	521.61
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturers Target	Calcium Channel
Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

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