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Azido-PEG5-acid

Azido-PEG5-acid

Item no.	HY-130572-250mg
Manufacturer	MedChem Express
CASRN	1425973-16-5
Amount	250 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C13H25N3O7
Citations	[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.<br>[2]Zolotarskaya OY, et al. Click synthesis of a polyamidoamine dendrimer-based camptothecin prodrug. RSC Adv. 2015;5(72):58600-58608. Epub 2015 Jun 29.
Smiles	O=C(O)CCOCCOCCOCCOCCOCCN=[N+]=[N-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Azido-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs, such as the conjugate CPT-APO (CPT: Camptothecin (HY-16560)). Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2]. Azido-PEG5-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	335.35
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturers Target	ADC Linker; PROTAC Linkers
Isoform	Non-cleavable Linker; PEG Linkers
Pathway	Antibody-drug Conjugate/ADC Related; PROTAC
Manufacturers Product type	ADC Related

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