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Cediranib (maleate)

Cediranib (maleate)

Item no.	HY-13049-25mg
Manufacturer	MedChem Express
CASRN	857036-77-2
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.95
Formula	C29H31FN4O7
Citations	[1]Wedge SR, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res, 2005, 65(10), 4389-4400.
Smiles	O=C(O)/C=C\C(O)=O.FC1=C(OC2=C(C(C=C3OCCCN4CCCC4)=NC=N2)C=C3OC)C=CC5=C1C=C(C)N5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AZD-2171 maleate
Available
Product Description	Cediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	566.58
Clinical_Information	Phase 3
Manufacturers Research_Area	Cancer
Solubility	DMSO : ≥ 45 mg/mL\|H2O : 2 mg/mL (ultrasonic)
Manufacturers Target	Autophagy; PDGFR; VEGFR
Isoform	PDGFRα; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Pathway	Autophagy; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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