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Propargyl-PEG4-acid

Propargyl-PEG4-acid

Item no.	HY-130481-100mg
Manufacturer	MedChem Express
CASRN	1415800-32-6
Amount	100 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	97.0
Formula	C12H20O6
Citations	[1]Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.
Smiles	C#CCOCCOCCOCCOCCC(O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	260.28
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturers Target	PROTAC Linkers
Isoform	PEG Linkers
Pathway	PROTAC
Manufacturers Product type	Reference compound

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