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SKF 83959

SKF 83959

Item no.	HY-130344-10mM
Manufacturer	MedChem Express
CASRN	80751-85-5
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1 ea 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.94
Formula	C18H20ClNO2
Citations	[1] Sheng G, et al. SKF83959 Has Protective Effects in the Scopolamine Model of Dementia. Biol Pharm Bull. 2018;41(3):427-434.<br/>[2]Jin LQ, et al. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J Neurochem. 2003;85(2):378-386.<br/>[3]Neumeyer JL, et al. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol. 2003;474(2-3):137-140.<br/>[4]Guo L, et al. SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol Pharmacol. 2013;83(3):577-586.
Smiles	OC1=C(O)C=C2C(C3=CC=CC(C)=C3)CN(C)CCC2=C1Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression[1][2][3][4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	317.81
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Dopamine Receptor; Sigma Receptor
Manufacturers Target	Dopamine Receptor; Sigma Receptor
Isoform	D1 Receptor; D2 Receptor; D3 Receptor; D5 Receptor; Sigma 1 Receptor
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mM/1mL

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