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Ivacaftor-d18

Ivacaftor-d18

Item no.	HY-13017S2-1ea
Manufacturer	MedChem Express
CASRN	1413431-05-6
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	92.92
Formula	C24H10D18N2O3
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.<br/>[2]Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570.
Smiles	[2H]C([2H])([2H])C(C([2H])([2H])[2H])(C1=C(C=C(C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C1)O)NC(C2=CNC3=CC=CC=C3C2=O)=O)C([2H])([2H])[2H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VX-770-d18
Available
Product Description	Ivacaftor-d18 is the deuterium labeled Ivacaftor[1]. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively[2].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	410.60
Clinical Information	No Development Reported
Manufacturers Research Area	Endocrinology
Solubility	10 mM in DMSO
Target	Autophagy; CFTR
Manufacturers Target	Autophagy; CFTR
Manufacturers Pathway	Autophagy; Membrane Transporter/Ion Channel
Manufacturers Product type	Isotope-Labeled Compounds

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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