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GSK3368715 (dihydrochloride)

GSK3368715 (dihydrochloride)

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Item no.	HY-128717A-100mg
CASRN	1628925-77-8
eClass 6.1	30220300
eClass 9.0	32160605
Available
Alias	EPZ019997 (dihydrochloride)
Purity	99.80
Product Description	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity[1].
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	439.46
Clinical_Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	DMSO : 230 mg/mL (ultrasonic)\|H2O : 140 mg/mL (ultrasonic)
Manufacturers Target	Histone Methyltransferase
Isoform	PRMT1; PRMT3; PRMT4; PRMT6; PRMT8
Pathway	Epigenetics

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