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ROR agonist-1

ROR agonist-1

Item no.	HY-128353-1ea
Manufacturer	MedChem Express
CASRN	2361528-74-5
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Small Molecules
Specific against	other
Formula	C21H20F6N2O5S
Citations	[1]von Berg S, et al. Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2. ACS Med Chem Lett. 2019 May 29;10(6):972-977.
Smiles	O=C([C@H](NC(C)=O)C1=CC=C(S(=O)(CC)=O)C=C1)NC2=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1].
Shipping	Room temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	526.45
Clinical_Information	No Development Reported
Manufacturers Research_Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturers Target	ROR
Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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