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ERK5-IN-2

ERK5-IN-2

Item no.	HY-128341-5mg
Manufacturer	MedChem Express
CASRN	1888305-96-1
Amount	5 mg
Quantity options	100 mg 10mM*1 mL 10 mg 1mg 25 mg 50 mg 5 mg
Category	Neuroscience Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.97
Formula	C17H11BrFN3O2
Citations	[1]Myers SM, et al. Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. Eur J Med Chem. 2019 May 25;178:530-543.
Smiles	FC1=CC=CC(Br)=C1C(C2=CNC(C(NC3=CC=CN=C3)=O)=C2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1888305-96-1
Available
Product Description	ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. ERK5-IN-2 does not interact with the BRD4 bromodomain. ERK5-IN-2 suppresses both tumor xenograft growth and basic fibroblast growth factor (bFGF) driven Matrigel plug angiogenesis[1].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	388.19
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Cardiovascular Disease
Solubility	DMSO : 250 mg/mL (ultrasonic)
Target	ERK
Manufacturers Target	ERK
Isoform	ERK5
Manufacturers Pathway	MAPK/ERK Pathway; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-128341-5mg-safety-datasheet.pdf