Comparison

Diflapolin European Partner

Item no. HY-128171-10mM
Manufacturer MedChem Express
CASRN 724453-98-9
Amount 10mM/1mL
Quantity options 100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.67
Formula C22H17Cl2N3O2S
Citations [1]Garscha U, et al. Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. Sci Rep. 2017;7(1):9398. Published 2017 Aug 24.
Smiles O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(OCC3=NC4=CC=CC=C4S3)C=C2C
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 724453-98-9
Similar products 724453-98-9
Available
Product Description
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of  30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM)[1].
StorageTemperature
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping
Room Temperature
Manufacturers Applications
COVID-19-immunoregulation
MolecularWeight
458.36
Clinical Information
No Development Reported
Manufacturers Research Area
Inflammation/Immunology
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Target
Epoxide Hydrolase; FLAP
Manufacturers Target
Epoxide Hydrolase; FLAP
Manufacturers Pathway
Immunology/Inflammation; Metabolic Enzyme/Protease
Manufacturers Product type
Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10mM/1mL
Available: In stock
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