ZL0580

Item no.	HY-126428-10mM
Manufacturer	MedChem Express
CASRN	2377151-10-3
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 250mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.26
Formula	C25H23F3N4O4S
Citations	[1]Niu Q, et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019 Jul 22;129(8):3361-3373.<br/>[2]Vansant G, et al. Block-And-Lock Strategies to Cure HIV Infection. Viruses. 2020 Jan 10;12(1). pii: E84.<br/>[3]Brasier AR, et al. Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling. Drug Discov Today. 2020 Jan;25(1):126-132.
Smiles	O=C(NC1=CC=C(S(N2CCC[C@H]2C(NC3=CC=CC=C3)=O)(=O)=O)C=C1)NC4=CC=C(C(F)(F)F)C=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2377151-10-3
Similar products	2377151-10-3
Available
Product Description	ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	532.53
Clinical Information	No Development Reported
Manufacturers Research Area	Infection; Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (ultrasonic)
Target	Epigenetic Reader Domain; HIV
Manufacturers Target	Epigenetic Reader Domain; HIV
Isoform	BRD4
Manufacturers Pathway	Anti-infection; Epigenetics
Manufacturers Product type	Reference compound

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