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CCR4 antagonist 2

CCR4 antagonist 2

Item no.	HY-125836-1ea
Manufacturer	MedChem Express
CASRN	2206788-99-8
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Small Molecules
Specific against	other
Formula	C26H28Cl2N6O
Citations	[1]Jackson JJ, et al. Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment. J Med Chem. 2019 Jul 11;62(13):6190-6213.
Smiles	ClC(C=C(Cl)C=C1)=C1[C@@H](C)N2N=C(C#N)C3=C2N=C(C4=CC[C@H](N5[C@H](CO)CCC5)[C@H](C)C4)C=N3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively[1].
Shipping	Room temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	511.45
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Endocrinology
Solubility	10 mM in DMSO
Manufacturers Target	CCR
Isoform	CCR4
Pathway	GPCR/G Protein; Immunology/Inflammation
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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