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Sigma-1 receptor antagonist 3

Sigma-1 receptor antagonist 3

Item no.	HY-125820-100mg
Manufacturer	MedChem Express
CASRN	1639220-17-9
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.47
Formula	C19H23ClFN3O
Citations	[1]Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.
Smiles	CC1=NC(C2=CC=C(F)C=C2)=NC(OCCCN3CCCCC3)=C1Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1639220-17-9
Similar products	1639220-17-9
Available
Product Description	Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 has the potential for the neuropathic pain[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	363.86
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 12.5 mg/mL (ultrasonic)
Target	Potassium Channel; Sigma Receptor
Manufacturers Target	Potassium Channel; Sigma Receptor
Isoform	Sigma 1 Receptor
Manufacturers Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

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