Col003

Item no.	HY-124817-25mg
Manufacturer	MedChem Express
CASRN	328565-16-8
Amount	25 mg
Quantity options	100 mg 10mM*1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.87
Formula	C14H11NO4
Citations	[1]Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
Smiles	O=CC1=CC(CC2=CC=CC=C2)=CC([N+]([O-])=O)=C1O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	328565-16-8
Available
Product Description	Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM). Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by destabilizing the collagen triple helix. Col003 can be used for the investigation of fibrosis[1]
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
MolecularWeight	257.24
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 50 mg/mL (ultrasonic)
Target	HSP
Manufacturers Target	HSP
Isoform	HSP40
Manufacturers Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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