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Rheb inhibitor NR1

Rheb inhibitor NR1

Item no.	HY-124798-10mg
Manufacturer	MedChem Express
CASRN	2216763-38-9
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.46
Formula	C25H19BrCl2N2O3S
Citations	[1]Mahoney SJ, et al. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun. 2018 Feb 7;9(1):548.
Smiles	O=C(C(N1CC2=CC=C(C(N(C)C)=O)C=C2)=CC3=C1C=C(SC4=CC=C(Cl)C(Cl)=C4)C=C3Br)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity[1]. (Rheb-IVK: Rheb-dependent mTORC1 kinase activity)
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	578.30
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)
Pathway	PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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