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AF40431

AF40431

Item no.	HY-124673-10mg
Manufacturer	MedChem Express
CASRN	181125-92-8
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 1mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.00
Formula	C17H21NO5
Citations	[1]Andersen JL, et al. Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):451-60.
Smiles	CC(C)C[C@@H](C(O)=O)NCC1=C(O2)C(C(C)=CC2=O)=CC=C1O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	181125-92-8
Available
Product Description	AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	319.35
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 25 mg/mL (ultrasonic; adjust pH to 1 with TFA)
Target	Neurotensin Receptor
Manufacturers Target	Neurotensin Receptor
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-124673-10mg-safety-datasheet.pdf