« Back
Home /
TEI-9647

TEI-9647

Item no.	HY-12398-5mg
Manufacturer	MedChem Express
CASRN	173388-20-0
Amount	5 mg
Quantity options	10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	85.50
Formula	C27H38O4
Citations	[1]Miura D, et al. Antagonistic action of novel 1α,25-dihydroxyvitamin D<sub>3</sub>-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1α,25-dihydroxyvitamin D<sub>3</sub>. J Biol Chem. 1999 Jun 4;274(23):16392-9. [2]Seiichi Ishizuka, et al. Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1α,25-dihydroxyvitamin D<sub>3</sub> from pagetic bone marrow cells. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):331-4. [3]Kazuya Takenouchi, et al. Synthesis and structure-activity relationships of TEI-9647 derivatives as Vitamin D<sub>3</sub> antagonists. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):31-4.
Smiles	O=C1O[C@@H](C[C@H]([C@H]2CC[C@@]3([H])/C(CCC[C@]23C)=C/C=C4C([C@@H](O)C[C@H](O)C\4)=C)C)CC1=C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	173388-20-0
Similar products	173388-20-0
Available
Product Description	TEI-9647, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α, 25(OH)2D3. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α, 25(OH)2D3. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease[1][2][3].
StorageTemperature	-20°C (Powder, protect from light, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	426.59
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease; Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	VD/VDR
Manufacturers Target	VD/VDR
Manufacturers Pathway	Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-12398-5mg-safety-datasheet.pdf