Item no. |
HY-12398-1mg |
Manufacturer |
MedChem Express
|
CASRN |
173388-20-0 |
Amount |
1 mg |
Quantity options |
10 mg
1 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
85.50 |
Formula |
C27H38O4 |
Citations |
[1]Miura D, et al. Antagonistic action of novel 1α,25-dihydroxyvitamin D<sub>3</sub>-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1α,25-dihydroxyvitamin D<sub>3</sub>. J Biol Chem. 1999 Jun 4;274(23):16392-9. [2]Seiichi Ishizuka, et al. Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1α,25-dihydroxyvitamin D<sub>3</sub> from pagetic bone marrow cells. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):331-4. [3]Kazuya Takenouchi, et al. Synthesis and structure-activity relationships of TEI-9647 derivatives as Vitamin D<sub>3</sub> antagonists. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):31-4. |
Smiles |
O=C1O[C@@H](C[C@H]([C@H]2CC[C@@]3([H])/C(CCC[C@]23C)=C/C=C4C([C@@H](O)C[C@H](O)C\4)=C)C)CC1=C |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
173388-20-0 |
Similar products |
173388-20-0 |
Available |
|
Product Description |
TEI-9647, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α, 25(OH)2D3. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α, 25(OH)2D3. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease[1][2][3]. |
StorageTemperature |
-20°C (Powder, protect from light, stored under nitrogen) |
Shipping |
Blue Ice |
Manufacturers Applications |
Metabolism-sugar/lipid metabolism |
MolecularWeight |
426.59 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Metabolic Disease; Inflammation/Immunology |
Solubility |
DMSO : 100 mg/mL (ultrasonic) |
Target |
VD/VDR |
Manufacturers Target |
VD/VDR |
Manufacturers Pathway |
Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.