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VT-1598 (tosylate)

VT-1598 (tosylate)

Item no.	HY-123777A-1ea
Manufacturer	MedChem Express
CASRN	2089321-00-4
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Formula	C38H28F4N6O5S
Citations	[1]Nathan P Wiederhold, et al. The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02233-18.<br>[2]Timothy J Break, et al. VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice. J Antimicrob Chemother. 2018 Aug 1;73(8):2089-2094.
Smiles	O=S(O)(C1=CC=C(C=C1)C)=O.FC(F)(C2=CC=C(C=N2)C#CC3=CC=C(C=C3)OCC4=CC=C(C=C4)C#N)[C@@](O)(C5=C(C=C(C=C5)F)F)CN6C=NN=N6
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	VT-1598 tosylate is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 tosylate shows anti-fungal activity against C. auris[1][2]. VT-1598 (tosylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Shipping	Room temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	756.72
Clinical_Information	Phase 1
Manufacturers Research_Area	Infection
Solubility	DMSO : 150 mg/mL (ultrasonic)
Manufacturers Target	Cytochrome P450
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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