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Sampatrilat

Sampatrilat

Item no.	HY-123348-50mg
Manufacturer	MedChem Express
CASRN	129981-36-8
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.22
Formula	C26H40N4O9S
Citations	[1]Sharma RK, et al. The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme. J Chem Inf Model. 2016 Dec 27;56(12):2486-2494.<br/>[2]Maki T, et al. Beneficial effects of sampatrilat, a novel vasopeptidase inhibitor, on cardiac remodeling and function of rats with chronic heart failure following left coronary artery ligation.J Pharmacol Exp Ther. 2003 Apr;305(1):97-105.
Smiles	OC([C@H](CNC([C@@H](NS(C)(=O)=O)CCCCN)=O)CC1(CCCC1)C(N[C@H](C(O)=O)CC2=CC=C(O)C=C2)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	UK-81252
Available
Product Description	Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation[1][2].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	584.68
Clinical Information	Phase 2
Manufacturers Research Area	Inflammation/Immunology; Cardiovascular Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Angiotensin-converting Enzyme (ACE); Neprilysin
Manufacturers Target	Angiotensin-converting Enzyme (ACE); Neprilysin
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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