Item no. |
HY-12326A-500ug |
Manufacturer |
MedChem Express
|
CASRN |
2734909-87-4 |
Amount |
500 ug |
Category |
|
Type |
Molecules |
Specific against |
other |
Purity |
99.53 |
Formula |
C20H22N10Na2O12P2 |
Dry ice |
Yes
|
Citations |
Cell Death Dis. 2022 Jul 28;13(7):653.<br>Gut Microbes. 2022 Jan-Dec;14(1):2119055.<br>[1]Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8).<br>[2]Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519.<br>[3]Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31.<br>[4]Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824. |
Smiles |
O[C@H]([C@@](OP(OC[C@](O[C@@H](N1C2=NC=NC(N)=C2N=C1)[C@@H]3O)([H])[C@@]3([H])O4)(O[Na])=O)([H])[C@](COP4(O[Na])=O)([H])O5)[C@@H]5N6C7=NC=NC(N)=C7N=C6 |
ECLASS 10.1 |
32169090 |
ECLASS 11.0 |
32169090 |
UNSPSC |
12000000 |
Alias |
Cyclic diadenylate (disodium); Cyclic-di-AMP (disodium) |
Available |
|
Product Description |
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4]. |
StorageTemperature |
-80°C, protect from light, stored under nitrogen |
Shipping |
Dry Ice |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
702.38 |
Clinical_Information |
No Development Reported |
Manufacturers Research_Area |
Inflammation/Immunology |
Solubility |
DMSO : 270 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL |
Manufacturers Target |
Bacterial; Endogenous Metabolite; STING |
Pathway |
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.