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20(S)-Hydroxycholesterol

20(S)-Hydroxycholesterol

Item no.	HY-12316-25mg
Manufacturer	MedChem Express
CASRN	516-72-3
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.70
Formula	C27H46O2
Citations	[1]Nachtergaele S, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol. 2012 Jan 8;8(2):211-20.<br/>[2]Nedelcu D, et al, Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol. 2013 Sep;9(9):557-64.
Smiles	C[C@@]1([C@@]2([H])[C@@](C)(O)CCCC(C)C)[C@](CC2)([H])[C@@](CC=C3[C@@]4(CC[C@H](O)C3)C)([H])[C@]4([H])CC1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	20α-Hydroxycholesterol
Available
Product Description	20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	402.65
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 12.5 mg/mL (ultrasonic)
Target	Endogenous Metabolite; Smo
Manufacturers Target	Endogenous Metabolite; Smo
Isoform	Human Endogenous Metabolite
Manufacturers Pathway	Metabolic Enzyme/Protease; Stem Cell/Wnt
Manufacturers Product type	Natural Products

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