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XR11576

XR11576

Item no.	HY-123143
Manufacturer	MedChem Express
CASRN	346689-77-8
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C23H24N4O2
Citations	[1]Di Nicolantonio F, et al. Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors. Anticancer Drugs. 2004 Oct;15(9):849-60.<br/>[2]Mistry P, et al. In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28.
Smiles	O=C(N[C@@H](CN(C)C)C)C1=C2C(N=C3C=CC4=C(C=CC=C4C3=N2)OC)=CC=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MLN576
Available
Product Description	XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC50: 6-47 nM)[1].
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	388.46
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	Topoisomerase
Manufacturers Target	Topoisomerase
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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