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(E/Z)-E64FC26

(E/Z)-E64FC26

Item no.	HY-122895A-100mg
Manufacturer	MedChem Express
CASRN	2285446-67-3
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.09
Formula	C19H23F3O2
Citations	[1]Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1.<br/>[2]Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022.
Smiles	OC1=CC2=C(/C(C=C2C(F)(F)F)=C/CCCCCCCC)C=C1O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2285446-67-3
Similar products	2285446-67-3
Available
Product Description	(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	340.38
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Apoptosis; PDI
Manufacturers Target	Apoptosis; PDI
Manufacturers Pathway	Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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