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Valiglurax

Valiglurax

Item no.	HY-122647-100mg
Manufacturer	MedChem Express
CASRN	1976050-09-5
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mM x 1 mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.96
Formula	C16H10F3N5
Citations	[1]Panarese JD, et, al. Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease. ACS Med Chem Lett. 2018 Oct 16;10(3):255-260.
Smiles	FC(C1=NC=CC2=C1C=CC(NC3=NNC4=NC=CC=C43)=C2)(F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VU0652957; VU2957
Available
Product Description	Valiglurax (VU0652957) is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of 64.6 nM and 197 nM for hmGlu4/Gqi5 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant. Valiglurax can be used in research of Parkinson's disease[1].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	329.28
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Target	mGluR
Manufacturers Target	mGluR
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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