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Tipepidine (hydrochloride)

Tipepidine (hydrochloride)

Item no.	HY-121685A-100mg
Manufacturer	MedChem Express
CASRN	1449686-84-3
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.92
Formula	C15H18ClNS2
Citations	[1]Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34.<br/>[2]Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78.
Smiles	CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1449686-84-3
Available
Product Description	Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron[1]. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect[2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	311.89
Clinical Information	Launched
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 41.67 mg/mL (ultrasonic)\|H2O : 3.33 mg/mL (ultrasonic)
Target	Potassium Channel
Manufacturers Target	Potassium Channel
Manufacturers Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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HY-121685A-100mg-safety-datasheet.pdf