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Demeclocycline

Demeclocycline

Item no.	HY-121268-50mg
Manufacturer	MedChem Express
CASRN	127-33-3
Amount	50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C21H21ClN2O8
Citations	J Photoch Photobio A. 2020 May. <br>Chemosphere. 2019 Jun;225:378-387. <br>Mol Syst Biol. 2022 Sep;18(9):e11081.<br>Patent. US20230014181.<br>[1]I Chopra, et al. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother. 1992 Mar;29(3):245-77.<br>[2]D Schnappinger, et al. Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Arch Microbiol. 1996 Jun;165(6):359-69.<br>[3]Marleen L A Kortenoeven, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1705-18.<br>[4]Susobhan Sarkar, et al. Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes. Front Immunol. 2020 Feb 21;11:272.
Smiles	O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])[C@H](O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4Cl)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Demeclocycline is an orally active tetracycline antibiotic. Demeclocycline impairs protein synthesis by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA. Demeclocycline shows anti-bacterial activitise to a wide variety of bacterial infections[1][2].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	464.85
Clinical_Information	Launched
Manufacturers Research_Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic)\|H2O : 40 mg/mL (ultrasonic)
Manufacturers Target	Antibiotic; Bacterial
Isoform	Tetracycline
Pathway	Anti-infection
Manufacturers Product type	Reference compound

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