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CXCR2-IN-2

CXCR2-IN-2

Item no.	HY-120878-25mg
Manufacturer	MedChem Express
CASRN	1838123-21-9
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Neuroscience Neuroinflammation Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.52
Formula	C18H23ClN2O5S
Citations	[1]Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.
Smiles	O=C(N[C@H]1C(C)=CCC1)NC2=CC=C(Cl)C(S(=O)([C@]3(C)COCC3)=O)=C2O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1838123-21-9
Similar products	1838123-21-9
Available
Product Description	CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	414.90
Clinical_Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 240 mg/mL (ultrasonic)
Manufacturers Target	CXCR
Isoform	CXCR1; CXCR2
Pathway	GPCR/G Protein; Immunology/Inflammation

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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