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APX-115 (free base)

APX-115 (free base)

Item no.	HY-120801A-10mM
Manufacturer	MedChem Express
CASRN	1270084-92-8
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 1mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.11
Formula	C17H17N3O
Citations	[1]Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232.<br/>[2]Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431.
Smiles	OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Ewha-18278 (free base); Isuzinaxib (free base)
Available
Product Description	APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	279.34
Clinical Information	Phase 2
Manufacturers Research Area	Endocrinology; Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (ultrasonic)
Target	NADPH Oxidase
Manufacturers Target	NADPH Oxidase
Isoform	NOX1; NOX2; NOX4
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-120801A-10mM-safety-datasheet.pdf