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p-MPPI (hydrochloride)

p-MPPI (hydrochloride)

Item no.	HY-120738-10mM
Manufacturer	MedChem Express
CASRN	220643-77-6
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.81
Formula	C25H28ClIN4O2
Citations	[1]Sørensen E, et al. The selective 5-HT(1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121(1-2):181-7.<br/>[2]Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl). 1997 Feb;129(4):365-71.
Smiles	O=C(C1=CC=C(C=C1)I)N(C2=NC=CC=C2)CCN3CCN(CC3)C4=CC=CC=C4OC.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	220643-77-6
Similar products	220643-77-6
Available
Product Description	p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	578.87
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 17.86 mg/mL (ultrasonic)\|H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Target	5-HT Receptor
Manufacturers Target	5-HT Receptor
Isoform	5-HT1 Receptor
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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Amount: 10mM/1mL

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