IOX4

Item no.	HY-120110-10mM
Manufacturer	MedChem Express
CASRN	1154097-71-8
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.83
Formula	C15H16N6O3
Citations	[1]Chan MC, et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS One. 2015 Jul 6;10(7):e0132004.
Smiles	O=C(C1=CC=C(N2NC=C(N3N=NC=C3)C2=O)N=C1)OC(C)(C)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1154097-71-8
Available
Product Description	IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	328.33
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)
Target	HIF/HIF Prolyl-Hydroxylase
Manufacturers Target	HIF/HIF Prolyl-Hydroxylase
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-120110-10mM-safety-datasheet.pdf