DD1

Item no.	HY-120035-1mg
Manufacturer	MedChem Express
CASRN	187585-11-1
Amount	1mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C16H14N2O3
Citations	[1]Marion Piedfer, et al. p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochim Biophys Acta. 2013 Jun;1833(6):1316-28.
Smiles	O=C1C(N)=C(C2=CC=C(OC)C(N)=C2)OC3=CC=CC=C13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].
Shipping	Room temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	282.29
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Manufacturers Target	Apoptosis; Proteasome; Ribosomal S6 Kinase (RSK)
Isoform	p70S6K
Pathway	Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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