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GLPG2451

GLPG2451

Item no.	HY-119936-10mg
Manufacturer	MedChem Express
CASRN	2055015-61-5
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.68
Formula	C16H16F3N3O5S
Citations	[1]Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221.
Smiles	O=S(C1=CC=C(OC(F)(F)F)C=C1)(C2=CN=C(C(NC[C@@H](O)C)=O)C(N)=C2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2055015-61-5
Available
Product Description	GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	419.38
Clinical Information	Phase 1
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 250 mg/mL (ultrasonic)
Target	Autophagy; CFTR
Manufacturers Target	Autophagy; CFTR
Manufacturers Pathway	Autophagy; Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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HY-119936-10mg-safety-datasheet.pdf