« Back
Home /
Barbadin

Barbadin

Item no.	HY-119706-5mg
Manufacturer	MedChem Express
CASRN	356568-70-2
Amount	5 mg
Quantity options	10mM/1mL 1 mg 2 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.93
Formula	C19H15N3OS
Citations	[1]Beautrait A, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.<br/>[2]Thoria Donia, et al. β-Arrestin inhibition induces autophagy, apoptosis, G0/G1 cell cycle arrest in agonist-activated V2R receptor in breast cancer cells. Med Oncol. 2021 Mar 15;38(4):38.
Smiles	O=C1C(C(C2=CC=C(CC3=CC=CC=C3)C=C2)=CS4)=C4N=CN1N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	356568-70-2
Available
Product Description	Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors. Barbadin can induce apoptosis[1][2].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
MolecularWeight	333.41
Clinical Information	No Development Reported
Manufacturers Research Area	Others
Solubility	DMSO : 50 mg/mL (ultrasonic)
Target	Apoptosis; Arrestin
Manufacturers Target	Apoptosis; Arrestin
Manufacturers Pathway	Apoptosis; GPCR/G Protein
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-119706-5mg-safety-datasheet.pdf