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BW 755C

BW 755C

Item no.	HY-119671-10mg
Manufacturer	MedChem Express
CASRN	66000-40-6
Amount	10 mg
Quantity options	10 mg 1 ea 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	95.0
Formula	C10H10F3N3
Citations	[1]Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34(5):1560-70.<br/>[2]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.<br/>[3]Tanaka N, et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol. 1991 Feb;260(2 Pt 1):E170-4.
Smiles	NC1=NN(C2=CC=CC(C(F)(F)F)=C2)CC1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	229.20
Clinical Information	No Development Reported
Manufacturers Research Area	Endocrinology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	COX; Lipoxygenase
Manufacturers Target	COX; Lipoxygenase
Isoform	5-LOX; COX-1; COX-2
Manufacturers Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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