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S18-000003

S18-000003

Item no.	HY-119366-50mg
Manufacturer	MedChem Express
CASRN	2068119-11-7
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.31
Formula	C26H25F3N2O4S
Citations	[1]Sasaki Y, et, al. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553.<br/>[2]Imura C, et, al. A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations. J Dermatol Sci. 2019 Mar;93(3):176-185.
Smiles	FC1=C(NC(C(C)(C)C2=CC=C(NC(CC3=CC=C(S(CC)(=O)=O)C=C3)=O)C=C2F)=O)C=CC(F)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2068119-11-7
Similar products	2068119-11-7
Available
Product Description	S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of 50>10 μM). S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations[1][2].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	518.55
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	ROR
Manufacturers Target	ROR
Isoform	RORγ
Manufacturers Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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