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N-Desmethyl Sildenafil

N-Desmethyl Sildenafil

Item no.	HY-117605-10mM
Manufacturer	MedChem Express
CASRN	139755-82-1
Amount	10mM/1mL
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.86
Formula	C21H28N6O4S
Citations	[1]Péter Barabás, et al. Sildenafil, N-desmethyl-sildenafil and Zaprinast enhance photoreceptor response in the isolated rat retina. Neurochem Int. 2003 Nov;43(6):591-5.<br>[2]Rikako Takahiro, et al. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65.
Smiles	CCOC1=C(C=C(S(N2CCNCC2)(=O)=O)C=C1)C3=NC4=C(C(N3)=O)N(C)N=C4CCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Desmethylsildenafil; UK-103,320
Available
Product Description	N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	460.55
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cardiovascular Disease
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturers Target	Phosphodiesterase (PDE)
Isoform	PDE5
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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