α5IA

Item no.	HY-116622-5mg
Manufacturer	MedChem Express
CASRN	215874-86-5
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	97.0
Formula	C17H14N8O2
Citations	[1]Chitra Vinnakota, et al. An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures. Int J Mol Sci. 2020 May 6;21(9):3284. <br>[2]Arnaud Duchon, et al. Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABAA inverse agonist. Br J Pharmacol. 2020 Mar;177(5):1106-1118.
Smiles	CN1N=NC(COC(C2=C3C=CC=C2)=NN4C3=NN=C4C5=NOC(C)=C5)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	L-822179
Available
Product Description	α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential[1].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
MolecularWeight	362.35
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturers Target	GABA Receptor
Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

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