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Sparstolonin B

Sparstolonin B

Item no.	HY-116213-10mM
Manufacturer	MedChem Express
CASRN	1259330-61-4
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.54
Formula	C15H8O5
Citations	[1]Liang Q, et al. Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. J Biol Chem. 2011;286(30):26470-26479.<br/>[2]Deng X, et al. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription. Virol J. 2015;12:108. Published 2015 Jul 25.<br/>[3]Kumar A, et al. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells [published correction appears in PLoS One. 2016;11(7):e0159082]. PLoS One. 2014;9(5):e96343. Published 2014 May 1.
Smiles	O=C1OC=C2C3=C(OC4=C2C1=C(O)C=C4)C=CC(O)=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	268.22
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO : 10 mg/mL (ultrasonic; warming)
Target	HIV; Toll-like Receptor (TLR)
Manufacturers Target	HIV; Toll-like Receptor (TLR)
Isoform	HIV-1; TLR2; TLR4
Manufacturers Pathway	Anti-infection; Immunology/Inflammation
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10mM/1mL

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