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JNJ-26076713

JNJ-26076713

Item no.	HY-116030-1ea
Manufacturer	MedChem Express
CASRN	669076-03-3
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Formula	C29H38N4O3
Citations	[1]Santulli RJ, et, al. Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats. J Pharmacol Exp Ther. 2008 Mar;324(3):894-901.
Smiles	O=C(C[C@@H]([C@H]1CNC2=C(C1)C=CC=C2)CC3CCN(CC3)C(CCC4=CC=C5CCCN=C5N4)=O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	JNJ-26076713 is a potent and orally active alpha V integrin antagonist with IC50 values of 2.3 nM and 6.3 nM for alpha(V)beta(3) and alpha(V)beta(5), respectively. JNJ-26076713 inhibits retinal neovascularization[1].
Shipping	Room temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	490.64
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Solubility	10 mM in DMSO
Target	Integrin
Manufacturers Target	Integrin
Isoform	αvβ3; αvβ5
Manufacturers Pathway	Cytoskeleton
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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