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Etilevodopa (hydrochloride)

Etilevodopa (hydrochloride)

Item no.	HY-116016A-100mg
Manufacturer	MedChem Express
CASRN	39740-30-2
Amount	100 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.40
Formula	C11H16ClNO4
Citations	[1]Blindauer K, et al. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. Arch Neurol. 2006 Feb;63(2):210-6.<br>[2]Djaldetti R, et al. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson's disease: an open-label, randomized, crossover study. Clin Neuropharmacol. 2003 Nov-Dec;26(6):322-6.<br>[3]Haddad F, et al. Dopamine and Levodopa Prodrugs for the Treatment of Parkinson's Disease. Molecules. 2017 Dec 25;23(1). pii: E40.
Smiles	N[C@@H](CC1=CC=C(O)C(O)=C1)C(OCC)=O.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	L-DOPA ethyl ester (hydrochloride); Levodopa ethyl ester (hydrochloride)
Available
Product Description	Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine[1][2][3].
StorageTemperature	4°C (Powder, protect from light, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	261.70
Clinical_Information	Phase 3
Manufacturers Research_Area	Neurological Disease
Solubility	H2O : 125 mg/mL (ultrasonic)
Manufacturers Target	Dopamine Receptor; Drug Metabolite
Pathway	GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Manufacturers Product type	Reference compound

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