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P62-mediated mitophagy inducer

P62-mediated mitophagy inducer

Item no.	HY-115576-5mg
Manufacturer	MedChem Express
CASRN	1809031-84-2
Amount	5 mg
Quantity options	100 mg 10mM*1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.49
Formula	C14H9IN4O2
Citations	[1]East DA, et al. PMI: a ΔΨm independent pharmacological regulator of mitophagy. Chem Biol. 2014 Nov 20;21(11):1585-96.
Smiles	O=[N+](C1=CC(C2=CN(C3=CC=CC(I)=C3)N=N2)=CC=C1)[O-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PMI
Available
Product Description	P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential[1].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	392.15
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Neurological Disease
Solubility	DMSO : 8.33 mg/mL (ultrasonic)
Target	Autophagy; Mitophagy; p62
Manufacturers Target	Autophagy; Mitophagy; p62
Manufacturers Pathway	Autophagy
Manufacturers Product type	Reference compound

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HY-115576-5mg-safety-datasheet.pdf