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BCI (hydrochloride)

BCI (hydrochloride)

Item no.	HY-115502A-25mg
Manufacturer	MedChem Express
CASRN	95130-23-7
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.89
Formula	C22H24ClNO
Citations	Cancers (Basel). 2023 Sep 6, 15(18), 4442.<br>Development. 2023 Feb 13;dev.201090.<br>Phytother Res. 2023 Mar 3.<br>bioRxiv. 2024 Feb 5.<br>Cells. 2022 Feb 19;11(4):732.<br>Dis Model Mech. 2023 May 1;16(5):dmm049662.<br>Kaohsiung J Med Sci. 2022 Dec 16.<br>Neural Regen Res. 2023.<br>[1]Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.<br>[2]Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681.
Smiles	O=C1/C(C(NC2CCCCC2)C3=C1C=CC=C3)=C/C4=CC=CC=C4.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(E)-BCI (hydrochloride)
Available
Product Description	BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research[1][2].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	353.89
Clinical_Information	No Development Reported
Manufacturers Research_Area	Inflammation/Immunology
Solubility	DMSO : 15.62 mg/mL (ultrasonic)
Manufacturers Target	Phosphatase
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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Amount: 25 mg

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