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Taurohyodeoxycholic acid (sodium)

Taurohyodeoxycholic acid (sodium)

Item no.	HY-114360A-100mg
Manufacturer	MedChem Express
CASRN	38411-85-7
Amount	100 mg
Quantity options	100 mg 1 ea 50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C26H44NNaO6S
Citations	[1]Roda A, et al. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. Hepatology. 1998 Feb;27(2):520-5. <br/>[2]Angelico M, et al. Dissolution of human cholesterol gallstones in bile salt/lecithin mixtures: effect of bile salt hydrophobicity and various pHs. Scand J Gastroenterol. 1995 Dec;30(12):1178-85. <br/>[3]Angelico M, et al. Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat. Dig Dis Sci. 1994 Nov;39(11):2389-97. <br/>[4]Roda A, et al. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. Hepatology. 1998 Feb;27(2):520-5. <br/>[5]Solmon Kusuma S, et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma[J]. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 2014, 14(9): 1237-1248.
Smiles	C[C@@]12[C@]3([H])[C@](C[C@@H]([C@]1([H])C[C@@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
MolecularWeight	521.69
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	H2O : 62.5 mg/mL (ultrasonic)
Target	Interleukin Related; TNF Receptor
Manufacturers Target	Interleukin Related; TNF Receptor
Isoform	IL-6; TNFRSF1A/CD120a
Manufacturers Pathway	Apoptosis; Immunology/Inflammation
Manufacturers Product type	Biochemical Assay Reagents

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