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7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

Item no.	HY-113969-1ea
Manufacturer	MedChem Express
CASRN	61563-24-4
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Formula	C9H9Cl2N
Citations	[1]Pramod C Nair, et al. Using Theory to Reconcile Experiment: The Structural and Thermodynamic Basis of Ligand Recognition by Phenylethanolamine N-Methyltransferase (PNMT). J Chem Theory Comput. 2011 May 10;7(5):1458-68.<br/>[2]N Y Liang, et al. Inhibitors of phenylethanolamine-N-methyltransferase. 2. Comparison of nonaromatic analogs of phenylethanolamines, 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) and 2,3-dichloro-alpha-methylbenzylamine: effects on rat brain and adrenal catecholamine content and blood pressure. J Pharmacol Exp Ther. 1982 Nov;223(2):382-7.
Smiles	ClC1=C(Cl)C=CC2=C1CNCC2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	7, 8-Dichloro-1, 2, 3, 4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7, 8-Dichloro-1, 2, 3, 4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease[1].
Shipping	Room temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	202.08
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	10 mM in DMSO
Target	Endogenous Metabolite
Manufacturers Target	Endogenous Metabolite
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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