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Z-Asp-CH2-DCB

Z-Asp-CH2-DCB

Item no.	HY-113953-10mg
Manufacturer	MedChem Express
CASRN	153088-73-4
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.28
Formula	C20H17Cl2NO7
Citations	[1]Krakauer T, et al. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clin Diagn Lab Immunol. 2004 May;11(3):621-4.<br>[2]Kasahara Y, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000 Dec;106(11):1311-9.<br>[3]Twumasi P, et al. Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures. BMC Plant Biol. 2010 Aug 6;10:162.
Smiles	O=C(OCC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(O)=O)=O)C2=C(Cl)C=CC=C2Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development[1][2][3].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	454.26
Clinical_Information	No Development Reported
Manufacturers Research_Area	Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; Caspase
Pathway	Apoptosis
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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