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(S)-Coriolic acid

(S)-Coriolic acid

Item no.	HY-113884B-100mg
Manufacturer	MedChem Express
CASRN	29623-28-7
Amount	100 mg (337.33 mM x 1 mL in Ethanol)
Quantity options	100 mg (337.33 mM x 1 mL in Ethanol) 100 ug (337.33 uM * 1 mL in Ethanol) 1 ea 250 mg (337.33 mM x 2 mL in Ethanol) 250 ug (337.33 uM * 2.5 mL in Ethanol)
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.0
Citations	[1]Mabalirajan U, et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. Sci Rep. 2013;3:1349.<br/>[2]Ogawa E, et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. J Invest Dermatol. 2011;131(3):604-612.<br/>[3]Yuan H, et al. 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. Thorax. 2010;65(4):321-326.
Smiles	CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	13(S)-HODE
Available
Product Description	(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury[1][2][3].
StorageTemperature	Solution, -20°C, 2 years
Shipping	Blue Ice
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	296.44
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Inflammation/Immunology
Solubility	10 mM in DMSO
Target	Mitochondrial Metabolism; PPAR
Manufacturers Target	Mitochondrial Metabolism; PPAR
Manufacturers Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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Amount: 100 mg (337.33 mM x 1 mL in Ethanol)

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