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α-Hydroxyglutaric acid

α-Hydroxyglutaric acid

Item no.	HY-113038B-25mg
Manufacturer	MedChem Express
CASRN	2889-31-8
Amount	25mg (67.52 mM * 2.5mL in Ethanol)
Quantity options	100 mg 10mg (67.52 mM * 1mL in Ethanol) 25mg (67.52 mM * 2.5mL in Ethanol) 50 mg 5mg (67.52 mM * 0.5mL in Ethanol)
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.0
Formula	C5H8O5
Citations	[1]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.
Smiles	O=C(O)C(O)CCC(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid
Available
Product Description	α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].
StorageTemperature	Solution, -20°C, 2 years
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	148.11
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	Endogenous Metabolite; Histone Demethylase
Manufacturers Target	Endogenous Metabolite; Histone Demethylase
Isoform	Human Endogenous Metabolite; Microbial Metabolite
Manufacturers Pathway	Epigenetics; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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Amount: 25mg (67.52 mM * 2.5mL in Ethanol)

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