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V-9302 (hydrochloride)

V-9302 (hydrochloride)

Item no.	HY-112683A-100mg
Manufacturer	MedChem Express
CASRN	2416138-42-4
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.64
Formula	C34H39ClN2O4
Citations	J Nanobiotechnology. 2022 May 6;20(1):216.<br/>Research Square Print. 2023 Jan 31.<br/>Cell Death Dis. 2024 Feb 5;15(2):111.<br/>Cell Metab. 2022 Nov 11;S1550-4131(22)00490-9.<br/>Front Pharmacol. 2021 May 14;12:671328.<br/>J Biol Chem. 2022 Feb 18;101753.<br/>J Control Release. 2023 Apr 19;357:460-471.<br/>Magn Reson Imaging. 2022 Aug 24;S0730-725X(22)00149-7.<br/>Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2319429121.<br/>[1]Schulte ML, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb;24(2):194-202.<br/>[2]Jin H, et al. A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer. Elife. 2020;9:e56749. Published 2020 Oct 5.<br/>[3]Edwards DN, et al. Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. J Clin Invest. 2021;131(4):e140100.
Smiles	O=C(O)[C@@H](N)CCN(CC1=CC=CC=C1OCC2=CC=CC(C)=C2)CC3=CC=CC=C3OCC4=CC=CC(C)=C4.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	575.14
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 50 mg/mL (ultrasonic)
Target	ASCT
Manufacturers Target	ASCT
Isoform	ASCT2
Manufacturers Product type	Reference compound

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HY-112683A-100mg-safety-datasheet.pdf